{"id":273,"date":"2020-03-10T14:18:34","date_gmt":"2020-03-10T14:18:34","guid":{"rendered":"http:\/\/xenopat.com\/advanced-preclinical-services\/bibliography\/"},"modified":"2020-04-02T09:53:37","modified_gmt":"2020-04-02T09:53:37","slug":"bibliografia","status":"publish","type":"page","link":"http:\/\/xenopat.com\/es\/servicios-preclinicos-avanzados\/bibliografia\/","title":{"rendered":"Bibliograf\u00eda"},"content":{"rendered":"\t\t
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Bibliograf\u00eda<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Orthoxenografts\u00ae<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Interrogating open issues in cancer precision medicine with patient-derived xenografts<\/strong><\/em><\/a>
<\/strong><\/em>Nat Rev Cancer<\/span>. 2017 Jan 20<\/span>.
Byrne AT, Alf\u00e9rez DG, Amant F, Annibali D, Arribas J, Biankin AV, Bruna A, Budinsk\u00e1 E, Caldas C, Chang DK, Clarke RB, Clevers H, Coukos G, Dangles-Marie V, Eckhardt SG, Gonzalez-Suarez E, Hermans E, Hidalgo M, Jarzabek MA, de Jong S, Jonkers J, Kemper K, Lanfrancone L, M\u00e6landsmo GM, Marangoni E, Marine JC, Medico E, Norum JH, Palmer HG, Peeper DS, Pelicci PG, Piris-Gimenez A, Roman-Roman S, Rueda OM, Seoane J, Serra V, Soucek L, Vanhecke D,\u00a0Villanueva A, Vinolo E, Bertotti A, Trusolino L.<\/p>

\u00a0<\/p>

Pulm\u00f3n<\/h5>

SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo.\u00a0<\/a> <\/strong><\/em><\/p>

Nat Med. 2018 Jul;24(7):961-967.
Mainardi S, Mulero-S\u00e1nchez A, Prahallad A, Germano G, Bosma A, Krimpenfort P, Lieftink C, Steinberg JD, de Wit N, Gon\u00e7alves-Ribeiro S, Nadal E, Bardelli A,\u00a0Villanueva A, Bernards R.<\/p>

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Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies\u00a0B2M\u00a0Inactivation Impairing Immunorecognition.<\/a>
<\/strong><\/em>Clin Cancer Res. 2017 Jun 15;23(12):3203-3213.
Pereira C, Gimenez-Xavier P, Pros E, Pajares MJ, Moro M, Gomez A, Navarro A, Condom E, Moran S, Gomez-Lopez G, Gra\u00f1a O, Rubio-Camarillo M, Martinez-Mart\u00ed A, Yokota J, Carretero J, Galbis JM, Nadal E, Pisano D, Sozzi G, Felip E, Montuenga LM, Roz L,\u00a0Villanueva A, Sanchez-Cespedes M.<\/p>

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Dual MET and ERBB inhibition overcomes intratumor plasticity in osimertinib-resistant-advanced non-small-cell lung cancer (NSCLC).<\/a>
<\/strong><\/em>Ann Oncol. 2017 Oct 1;28(10):2451-2457.
Martinez-Marti A, Felip E, Matito J, Mereu E, Navarro A, Cedr\u00e9s S, Pardo N, Martinez de Castro A, Remon J, Miquel JM, Guillaumet-Adkins A, Nadal E, Rodriguez-Esteban G, Arqu\u00e9s O, Fasani R, Nuciforo P, Heyn H,\u00a0Villanueva A, Palmer HG, Vivancos A.<\/p>

\u00a0<\/div>
Single-cell transcriptome conservation in cryopreserved cells and tissues.<\/strong><\/em><\/a>
<\/strong><\/em>Genome Biol. 2017 Mar 1;18(1):45.<\/span>
Guillaumet-Adkins A, Rodr\u00edguez-Esteban G, Mereu E, Mendez-Lago M, Jaitin DA,\u00a0Villanueva A,\u00a0Vidal A, Martinez-Marti A, Felip E, Vivancos A, Keren-Shaul H, Heath S, Gut M, Amit I, Gut I, Heyn H.<\/div>
\u00a0<\/div>
KRAS-driven lung adenocarcinoma: combined DDR1\/Notch inhibition as an effective therapy<\/strong><\/em><\/a>
<\/strong><\/em>ESMO Open<\/span>. 2016 Sep 6;1(5):e000076.
Ambrogio C, Nadal E,\u00a0Villanueva<\/span>\u00a0A, G\u00f3mez-L\u00f3pez G, Cash TP, Barbacid M, Santamar\u00eda D.<\/div>
\u00a0<\/div>

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma<\/strong><\/em><\/a>
Nat Med. 2016 Feb 8.
Ambrogio C, G\u00f3mez-L\u00f3pez G, Falcone M,\u00a0Vidal A, Nadal E, Crosetto N, Blasco RB, Fern\u00e1ndez-Marcos PJ, S\u00e1nchez-C\u00e9spedes M, Ren X, Wang Z,Ding K, Hidalgo M, Serrano M,\u00a0Villanueva<\/span>\u00a0A, Santamar\u00eda D,\u00a0Barbacid<\/span>\u00a0M.<\/p>

\u00a0<\/p>

PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion<\/b><\/em><\/a>
<\/em><\/b>Cancer Res. 2015 Apr 1;75(7):1287-97.
Bonastre E, Verdura S, Zondervan I, Facchinetti F, Lantuejoul S, Chiara MD, Rodrigo JP, Carretero J, Condom E,\u00a0Vidal A, Sidransky D,\u00a0Villanueva A, Roz L, Brambilla E, Savola S, Sanchez-Cespedes M.<\/p>

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Modelling lung cancer evolution and pre-clinical responseallografts by orthotopic mouse<\/b><\/em><\/a>
<\/em><\/b>Cancer Res. 2014 Nov 1;74(21):5978-88.
Ambrogio C, Carmona FJ,\u00a0Vidal A, Falcone M, Nieto P, Romero OA, Puertas S, Vizoso M, Nadal E, Poggio T, Sanchez-Cespedes M, Esteller M, Mulero F, Voena C, Chiarle R, Barbacid M, Santamaria D,\u00a0Villanueva A.<\/p>

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The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer<\/b><\/em><\/a>
<\/em><\/b>EMBO Mol Med. 2012 Jul;4(7):603-16.
Romero OA, Setien F, John S, Gimenez-Xavier P, G\u00f3mez-L\u00f3pez G, Pisano D, Condom E,\u00a0Villanueva A, Hager GL, Sanchez-Cespedes M.<\/p>

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Ovario<\/h5>

A Role for CXCR4 in Peritoneal and Hematogenous Ovarian Cancer Dissemination.<\/strong><\/em><\/a>
Mol Cancer Ther. 2018 Feb;17(2):532-543.
Figueras A, Alsina-Sanch\u00eds E, Lahiguera \u00c1, Abreu M, Muinelo-Romay L, Moreno-Bueno G, Casanovas O, Graupera M, Matias-Guiu X,\u00a0Vidal A,\u00a0Villanueva A, Vi\u00f1als F.<\/p>

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TGF\u03b2<\/a>\u00a0Controls Ovarian Cancer Cell Proliferation.<\/a>
<\/strong><\/em>Int J Mol Sci. 2017 Jul 30;18(8).
Alsina-Sanch\u00eds E, Figueras A, Lahiguera A, Gil-Mart\u00edn M, Pardo B, Piulats JM, Mart\u00ed L, Ponce J, Matias-Guiu X,\u00a0Vidal A,\u00a0Villanueva A, Vi\u00f1als F.<\/p>

\u00a0<\/p>

Single-cell transcriptome conservation in cryopreserved cells and tissues.<\/strong><\/em><\/a>
<\/strong><\/em>Genome Biol. 2017 Mar 1;18(1):45.<\/span>
Guillaumet-Adkins A, Rodr\u00edguez-Esteban G, Mereu E, Mendez-Lago M, Jaitin DA,\u00a0Villanueva A,\u00a0Vidal A, Martinez-Marti A, Felip E, Vivancos A, Keren-Shaul H, Heath S, Gut M, Amit I, Gut I, Heyn H.<\/p>

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<\/b>The TGF\u03b2 pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels<\/a>
<\/b><\/em>Int J Cancer<\/span>. 2016 Oct 15;139(8):1894-903.
Alsina-Sanchis E, Figueras A, Lahiguera \u00c1,\u00a0Vidal A, Casanovas O, Graupera M,\u00a0Villanueva A, Vi\u00f1als F.<\/p>

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Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis<\/b><\/em><\/a>
<\/em><\/b>Cancer Cell. 2014 Nov 10;26(5):707-21.
Melo SA, Sugimoto H, O\u2019Connell JT, Kato N,\u00a0Villanueva A,\u00a0Vidal A, Qiu L, Vitkin E, Perelman LT, Melo CA, Lucci A, Ivan C, Calin GA, Kalluri R.<\/p>

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BRCA1 epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer<\/b><\/em><\/a>
<\/em><\/b>Epigenetics. 2012 Nov;7(11):1225-9.
Stefansson OA,\u00a0Villanueva A,\u00a0Vidal A, Mart\u00ed L, Esteller M.<\/p>

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Lurbinectedin (PM01183), a new DNA minor groove binder, inhibits growth of orthotopic primary graft ofcisplatin-resistant epithelial ovarian cancer<\/b><\/em><\/a>
<\/em><\/b>Clinical Cancer Research. 2012 Oct 1;18(19):5399-411.
Vidal A, Mu\u00f1oz C, Guill\u00e9n MJ, Moret\u00f3 J, Puertas S, Mart\u00ednez-Iniesta M, Figueras A, Padull\u00e9s L, Garc\u00eda-Rodriguez FJ, Berdiel-Acer M, Pujana MA, Salazar R, Gil-Martin M, Mart\u00ed L, Ponce J, Mollev\u00ed DG, Capella G, Condom E, Vi\u00f1als F, Huertas D, Cuevas C, Esteller M, Avil\u00e9s P,\u00a0Villanueva A.<\/p>

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Colon<\/h5>

The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration.\u00a0\u00a0<\/strong><\/em><\/a>
Sci Rep. 2018 Aug 7;8(1):11797.
S\u00e1nchez-Botet A, Gasa L, Quandt E, Hern\u00e1ndez-Ortega S, Jim\u00e9nez J, Mezquita P, Carrasco-Garc\u00eda M\u00c0, Kron SJ,\u00a0Vidal A,\u00a0Villanueva A, Ribeiro MPC, Clotet J.<\/p>

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BRAF-induced tumorigenesis is IKK\u03b1-dependent but NF-\u03baB\u2013independent<\/b><\/em><\/a>
<\/em><\/b>Sci Signal. 2015 Apr 21;8(373):ra38.
Margalef P, Colomer C,\u00a0Villanueva A, Montagut C, Iglesias M, Bellosillo B, Salazar R, Mart\u00ednez-Iniesta M, Bigas A, Espinosa L.<\/p>

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A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect<\/b><\/em><\/a>
<\/em><\/b>Nat Commun. 2014 Apr 3;5:3608.
Lopez-Serra P, Marcilla M,\u00a0Villanueva A, Ramos-Fernandez A, Palau A, Leal L, Wahi JE, Setien-Baranda F, Szczesna K, Moutinho C, Martinez-Cardus A, Heyn H, Sandoval J, Puertas S,\u00a0Vidal A, Sanjuan X, Martinez-Balibrea E, Vi\u00f1als F, Perales JC, Bramsem JB, \u00d8rntoft TF, Andersen CL, Tabernero J, McDermott U, Boxer MB, Vander Heiden MG, Albar JP, Esteller M.<\/p>

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A truncated form of IKK\u03b1 is responsible for specific nuclear IKK activity in colorectal cancer<\/b><\/em><\/a>
<\/em><\/b>Cell Rep. 2012 Oct 25;2(4):840-54.
Margalef P, Fern\u00e1ndez-Majada V,\u00a0Villanueva A, Garcia-Carbonell R, Iglesias M, L\u00f3pez L, Mart\u00ednez-Iniesta M, Vill\u00e0-Freixa J, Mulero MC, Andreu M, Torres F, Mayo MW, Bigas A, Espinosa L.<\/p>

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Intronic RNAs mediate EZH2 regulation of epigenetic targets<\/b><\/em><\/a>
<\/em><\/b>Nat Struct Mol Biol. 2012 Jun 3;19(7):664-70.
Guil S, Soler M,\u00a0Portela A, Carr\u00e8re J, Fonalleras E, G\u00f3mez A,\u00a0Villanueva A, Esteller M.<\/p>

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Epigenetic disruption of cadherin-11 in human cancer metastasis<\/b><\/em><\/a>
<\/em><\/b>J Pathol. 2012 Oct;228(2):230-40.
Carmona FJ,\u00a0Villanueva A,\u00a0Vidal A, Mu\u00f1oz C, Puertas S, Penin RM, Gom\u00e0 M, Lujambio A, Piulats JM, Mes\u00eda R, S\u00e1nchez-C\u00e9spedes M, Man\u00f3s M, Condom E, Eccles SA, Esteller M.<\/p>

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Small molecule\u00a0<\/b>enoxacin<\/b>\u00a0is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated\u00a0<\/b>microRNA<\/b><\/em><\/a>\u00a0processing.<\/a>
<\/em><\/b>PNAS. 2011\u00a0March 15, vol. 108\u00a0no. 11\u00a04394-4399.
Melo S,\u00a0Villanueva A, Moutinho C, Davalos V, Spizzo R, Ivan C, Rossi S, Setien F, Casanovas O, Simo-Riudalbas L, Carmona J, Carrere J,\u00a0Vidal A, Aytes A, Puertas S, Ropero S, Kalluri R, Croce CM, Calin GA, Esteller M.<\/p>

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A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells<\/b><\/em><\/a>
<\/em><\/b>Cancer Cell. 2010 Oct 19;18(4):303-15.
Melo SA, Moutinho C, Ropero S, Calin GA, Rossi S, Spizzo R, Fernandez AF, Davalos V,\u00a0Villanueva A, Montoya G, Yamamoto H, Schwartz S Jr, Esteller M.<\/p>

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A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function<\/b><\/em><\/a>
<\/em><\/b>Nat Genet. 2009 Mar;41(3):365-70.
Melo SA, Ropero S, Moutinho C, Aaltonen LA, Yamamoto H, Calin GA, Rossi S, Fernandez AF, Carneiro F, Oliveira C, Ferreira B, Liu CG,\u00a0Villanueva A, Capella G, Schwartz S Jr, Shiekhattar R, Esteller M.<\/p>

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A microRNA DNA methylation signature for human cancer metastasis<\/b><\/em><\/a>
<\/em><\/b>PNAS. 2008 Sep 9;105(36):13556-61.
Lujambio A, Calin GA,\u00a0Villanueva A, Ropero S, S\u00e1nchez-C\u00e9spedes M, Blanco D, Montuenga LM, Rossi S, Nicoloso MS, Faller WJ, Gallagher WM, Eccles SA, Croce CM, Esteller M.<\/p>

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Sarcoma<\/h5>

Comprehensive establishment and characterization of orthoxenograft mouse models of malignant peripheral nerve sheath tumors for personalized medicine<\/b><\/em><\/a>
<\/em><\/b>EMBO Mol Med. 2015 Mar 25. pii: e201404430.
Castellsagu\u00e9 J, Gel B, Fern\u00e1ndez-Rodr\u00edguez J, Llatj\u00f3s R, Blanco I, Benavente Y, P\u00e9rez-Sidelnikova D, Garc\u00eda-Del Muro J, Vi\u00f1als JM,\u00a0Vidal A, Vald\u00e9s-Mas R, Terribas E, L\u00f3pez-Doriga A, Pujana MA, Capell\u00e1 G, Puente XS, Serra E,\u00a0Villanueva A, L\u00e1zaro C.<\/p>

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Mama<\/h5>

Tumor xenograft modeling identifies an association between TCF4 loss and breast cancer chemoresistance.<\/a>
<\/strong><\/em>Dis Model Mech. 2018 May 18;11(5).
Ruiz de Garibay G, Mateo F, Stradella A, Vald\u00e9s-Mas R, Palomero L, Serra-Musach J, Puente DA, D\u00edaz-Navarro A, Vargas-Parra G, Tornero E, Morilla I, Farr\u00e9 L, Martinez-Iniesta M, Herranz C, McCormack E,\u00a0Vidal A, Petit A, Soler T, L\u00e1zaro C, Puente XS,\u00a0Villanueva A, Pujana MA.<\/p>

\u00a0<\/p>

Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis<\/b><\/em><\/a>
<\/em><\/b>Cancer Cell. 2014 Nov 10;26(5):707-21.
Melo SA, Sugimoto H, O\u2019Connell JT, Kato N,\u00a0Villanueva A,\u00a0Vidal A, Qiu L, Vitkin E, Perelman LT, Melo CA, Lucci A, Ivan C, Calin GA, Kalluri R.<\/p>

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VAV3 mediates resistance to breast cancer endocrine therapy<\/b><\/em><\/a>
<\/em><\/b>Breast Cancer Res. 2014 May 28;16(3):R53.
Aguilar H, Urruticoechea A, Halonen P, Kiyotani K, Mushiroda T, Barril X, Serra-Musach J, Islam A, Caizzi L, Di Croce L, Nevedomskaya E, Zwart W, Bostner J, Karlsson E, P\u00e9rez Tenorio G, Fornander T, Sgroi DC, Garcia-Mata R, Jansen MP, Garc\u00eda N, Bonifaci N, Climent F, Soler MT, Rodr\u00edguez-Vida A, Gil M, Brunet J, Martrat G, G\u00f3mez-Bald\u00f3 L, Extremera AI, Figueras A, Balart J, Clarke R, Burnstein KL, Carlson KE, Katzenellenbogen JA, Vizoso M, Esteller M,\u00a0Villanueva A, Rodr\u00edguez-Pe\u00f1a AB, Bustelo XR, Nakamura Y, Zembutsu H, St\u00e5l O, Beijersbergen RL, Pujana MA.<\/p>

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The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31<\/b><\/em><\/a>
<\/em><\/b>Mol Cell. 2014 Mar 6;53(5):806-18
Vir\u00e9 E, Curtis C, Davalos V, Git A, Robson S,\u00a0Villanueva A,\u00a0Vidal A, Barbieri I, Aparicio S, Esteller M, Caldas C, Kouzarides T.<\/p>

\u00a0<\/p>

Test\u00edculo<\/h5>

Orthoxenografts of Testicular Germ Cell Tumors Demonstrate Genomic Changes Associated with Cisplatin Resistance and Identify PDMP as a Resensitizing Agent.\u00a0<\/a>
<\/strong><\/em>Clin Cancer Res. 2018 Aug 1;24(15):3755-3766.
Piulats JM,\u00a0Vidal A, Garc\u00eda-Rodr\u00edguez FJ, Mu\u00f1oz C, Nadal M, Moutinho C, Mart\u00ednez-Iniesta M, Mora J, Figueras A, Guin\u00f3 E, Padull\u00e9s L, Ayt\u00e9s \u00c0, Mollev\u00ed DG, Puertas S, Mart\u00ednez-Fern\u00e1ndez C, Castillo W, Juliachs M, Moreno V, Mu\u00f1oz P, Stefanovic M, Pujana MA, Condom E, Esteller M, Germ\u00e0 JR, Capella G, Farr\u00e9 L, Morales A, Vi\u00f1als F, Garc\u00eda-Del-Muro X, Cer\u00f3n J,\u00a0Villanueva A.<\/p>

\u00a0<\/p>

Effectivity of pazopanib treatment in orthotopic models of human testicular germ cell tumors<\/b><\/em><\/a>
<\/em><\/b>BMC Cancer. 2013 Aug 10;13:382
Juliachs M,\u00a0Vidal A, Del Muro XG, Piulats JM, Condom E, Casanovas O, Graupera M, Germ\u00e0 JR,\u00a0Villanueva A, Vi\u00f1als F.<\/p>

\u00a0<\/p>

Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors<\/b><\/em><\/a>
<\/em><\/b>Clin Cancer Res. 2009 May 15;15(10):3384-95.
Castillo-Avila W, Piulats JM, Garcia Del Muro X,\u00a0Vidal A, Condom E, Casanovas O, Mora J, Germ\u00e0 JR, Capell\u00e0 G,\u00a0Villanueva A, Vi\u00f1als F.<\/p>

\u00a0<\/p>

Glioblastoma<\/h5>

Radioresistance of mesenchymal glioblastoma initiating cells correlates with patient outcome and is associated with activation of inflammatory program.<\/strong><\/em><\/a>
Oncotarget. 2017 Jun 3;8(43):73640-73653.
Stanzani E, Mart\u00ednez-Soler F, Mateos TM, Vidal N,\u00a0Villanueva A, Pujana MA, Serra-Musach J, de la Iglesia N, Gim\u00e9nez-Bonaf\u00e9 P, Tortosa A.<\/p>

\u00a0<\/p>

Endometrio<\/h5>

Patient-Derived Xenograft Models for Endometrial Cancer Research.\u00a0<\/a>
<\/strong><\/em>Int J Mol Sci. 2018 Aug 17;19(8).
Moiola CP, Lopez-Gil C, Cabrera S, Garcia A, Van Nyen T, Annibali D, Fonnes T,\u00a0Vidal A,\u00a0Villanueva A, Matias-Guiu X, Krakstad C, Amant F, Gil-Moreno A, Colas E.<\/p>

\u00a0<\/p>

Melanoma<\/h5>

Evaluation of oncogenic cysteinyl leukotriene receptor 2 as a therapeutic target for uveal melanoma.\u00a0<\/a>
<\/strong><\/em>Cancer Metastasis Rev. 2018 Sep;37(2-3):335-345.
Slater K, Hoo PS, Buckley AM, Piulats JM,\u00a0Villanueva A,\u00a0Portela A, Kennedy BN.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Servicios Precl\u00ednicos Avanzados<\/h5>