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Serveis Preclínics Avançats - Xenopat

Serveis Preclínics Avançats

Els Serveis Preclínics Avançats de Xenopat ofereixen les eines més innovadores per al desenvolupament de nous fàrmacs oncològics. Xenopat ofereix als investigadors i a les companyies farmacèutiques l’OrthoXenoBank® format per més de 200 orthoxenografts®, models ortotòpics de diferents tumors humans implantats en el mateix òrgan del ratolí, incloent: colon, pulmó, mama, ovari i pàncrees. Els tumors estan histològica i genèticament caracteritzats i posseeixen diferents graus de resistència a diverses quimioteràpies. Els Serveis Preclínics Avançats de Xenopat volen convertir-se en un soci estratègic al llarg de tot el procés de desenvolupament de nous fàrmacs. Xenopat vol ajudar a les companyies farmacèutiques des dels primers assajos preclínics fins a la comercialització. Així els Serveis Preclínics Avançats de Xenopat poden resultar decisius tant durant la preclínica com al llarg de les diverses fases dels assajos clínics i fins i tot en etapes posteriors a la comercialització.

  • Generació de línies cel·lulars personalitzades (GFP, shRNA,etc.)
  • Determinació de la Màxima Dosi Tolerada (MTD). Pes. Autòpsia. Anàlisi histològica de la toxicitat.
  • Estudi de les pautes d’administració.
  • Identificació de combinacions de fàrmacs òptimes.
  • Evaluació de resposta a tractaments usant els mateixos parametres histopatològics que en humans.
  • Evaluació de l’aparició de tumors, taxa de creixement i potencial metastàsic amb o sense tractament.
  • Expressió gènica.
  • Estudis genètics i epigenètics.
  • Identificació/anàlisi de marcadores de respuesta.
  • Identificació de dianes terapèutiques/mecanisme d’acció en diversos sistemes biològics.
  • Generació d’orthoxenografts® personalitzats.
  • Caracterització de la subpoblació amb millor resposta.
  • Combinacions de fàrmacs.
  • Assajos co-clínics en humans i ratolins.
  • Identificació/anàlisi de marcadors de resposta en assajos co-clínics.
  • Reposicionament de fàrmacs.
  • Estudis de resistència adquirida a nous fàrmacs.

Descobreixi més

Els orthoxenografts® són models experimentals de ratolí en els quals s’implanta un petit fragment de tumor humà (implantació d’una espècie a una altra, xenograft) en el mateix òrgan d’origen (ortotopic).

L’OrthoXenoBank® és la col·lecció d’orthoxenografts® que Xenopat posa a disposició dels seus clients.

Publicacions científiques destacades referents als orthoxenografts®.
Contacte

Contacti avui amb l’equip de Xenopat per saber més sobre els Serveis Preclínics Avançats.

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