Orthoxenografts® are experimental mouse models in which a small piece of human tumor is implanted (implantation from one spices to another, xenograft) in the same organ of origin (orthotopically). Thus, we talk about Orthotopic Patient-Derived Xenografts (PDXs). Xenopat has developed the know-how to implant tumors in a 24 hour window after the tumor removal process occurred with extremely high engraftment rates.
Orthoxenografts® are characterized by:

  • Maintaining the histological, genetic and molecular characteristics of the original primary human tumor.
  • Reproducing growth and dissemination patterns of the original tumor.
  • Mimicking the drug response pattern of the original primary human tumor.
  • Achieving the maximum correlation between in vivo preclinical studies and human clinical trials.

Thus, orthoxenografts® are the most advanced preclinical models available to develop new antineoplastic drugs.

Due to their characteristics, othoxenografts® are the best available tools for:

  • Outsourcing the preclinical phases of drug development.
  • Targeting Product Profile processes.
  • Assisting Co-clinical studies (human/mice co-clinical trials), through the generation of orthoxenografts® derived from clinical trial participants.